Nurse-Administered Propofol Sedation by PCA Pump Versus Diazemuls / Pethidine in Outpatient Colonoscopy: A Randomized Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- diazemuls, pethidine
- Conditions
- Colonoscopy
- Sponsor
- North District Hospital
- Enrollment
- 194
- Primary Endpoint
- Pain
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
Colonoscopy is a common endoscopic procedure as an investigation of colorectal pathology. Different modalities of pain control have been described in the past. Propofol is a perfect drug for endoscopic procedure since it has the characteristic of fast onset, short half-life and early recovery. Its unfamiliarity and its potential cardiovascular and respiratory side effect make it unpopular to endoscopists. Recent reports showed propofol is safe in bolus titration by nurse in Caucasian in all endoscopic procedures. Our previous pilot study showed nurse administered propofol sedation (NAPS) is effective and safe and highly acceptable by Chinese patients. Here we conduct a randomized controlled study to compare the effectiveness of NAPS versus traditional sedation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 18-65 undergoing elective outpatient colonoscopy
Exclusion Criteria
- •American Society of Anesthesiologist Class III or above
- •History of difficult endotracheal intubation
- •Known allergy to propofol, eggs or soy products, opioid, benzodiazepines
- •previous colectomy
Arms & Interventions
1
Diazemuls-Pethidine
Intervention: diazemuls, pethidine
2
Propofol- Alfentanil
Intervention: Propofol and Alfentanil
Outcomes
Primary Outcomes
Pain
Time Frame: after recovery
Secondary Outcomes
- sedation(thorughout the procedure)