Pecto-Intercostal Fascial Block for Postoperative Analgesia After Cardiac Surgery
Overview
- Phase
- Phase 3
- Intervention
- Bupivacaine Group
- Conditions
- Coronary Artery Disease
- Sponsor
- Beth Israel Deaconess Medical Center
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Opioid Consumption
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The purpose of this study is to determine whether administration of a pecto-intercostal fascial plane block (PIFB) with bupivacaine is a more effective therapy for postoperative analgesia after cardiac surgery as compared to patients who receive a sham block of normal saline.
Detailed Description
The purpose of this study is to determine whether administration of a pecto-intercostal fascial plane block (PIFB) with bupivacaine is a more effective therapy for postoperative analgesia after cardiac surgery as compared to patients who receive a sham block of normal saline. Specific Aim 1: To determine whether or not a PIFB with bupivacaine can reduce postoperative pain after cardiac surgery. This will be assessed through: (Aim 1A) opioid consumption in the first 48 hours postoperatively (Aim 1B) patient self-reported pain scores during their hospital stay Specific Aim 2: To estimate the effect size in order to obtain information that can be used to power future research on the use of regional modalities of analgesia for cardiac surgeries.
Investigators
Balachundhar Subramaniam
Associate Professor of Anesthesia
Beth Israel Deaconess Medical Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Interventional Bupivacaine
20 cc of 0.25% bupivacaine on each side of the sternum at two time points after surgery and POD1
Intervention: Bupivacaine Group
Interventional Placebo
20 cc of saline on each side of the sternum at two time points after surgery and POD1
Intervention: Placebo
Outcomes
Primary Outcomes
Opioid Consumption
Time Frame: 48 hours
Total opioid consumption in the first 48 hours post-operatively, measured as milligram morphine equivalents (MME).
Secondary Outcomes
- Pain Scores(At 6-8 hourly intervals every day until discharge or 4 days)
- ICU Length of Stay(Time of ICU admission until time of discharge to hospital floor; through the hospital stay, an average of 5 days)
- Hospital Length of Stay(Measured in days admitted in the hospital, an average of 5 days)
- Number of Participants With Complications(7 days post-op on an average)