Comparison of the Effects of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Peripheral and Respiratory Muscle Oxygenation, Pulmonary Function, Exercise Capacity, and Peripheral Muscle Strength in Individuals With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- Peripheral and Respiratory Muscle Oxygenation
研究概览
简要总结
Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition marked by airflow limitation and chronic inflammation, leading to reduced exercise capacity, peripheral muscle dysfunction, and dyspnea. High-Intensity Interval Training (HIIT) may offer a promising alternative for patients with low exercise tolerance; however, evidence on its effectiveness remains limited.
This study aims to compare the effects of HIIT and Moderate-Intensity Continuous Training (MICT) on muscle oxygenation, pulmonary function, exercise capacity, and peripheral muscle strength in individuals with COPD. Participants will undergo an 8-week exercise program, twice weekly. HIIT will consist of 1-minute intervals at 90% and 30-40% of peak workload, while MICT will involve continuous cycling at 65% of peak workload. Outcomes will be assessed at baseline, week 4, and week 8. Data will be analyzed using SPSS. This study seeks to determine the more effective training modality to optimize COPD rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
Statistical Analyzer will be masked.
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with Chronic Obstructive Pulmonary Disease (COPD),
- •GOLD stage 2, 3, or 4,
- •Willing to participate in the study,
- •Aged between 40 and 80 years,
- •Clinically stable (no significant deterioration in the current medical condition, no recent initiation of a new treatment, and no complications requiring hospitalization).
排除标准
- •Presence of visual, auditory, vestibular, cognitive, or neurological impairments that may affect balance,
- •Any orthopedic, neurological, or cardiac conditions that may interfere with study participation or exercise,
- •Presence of serious chronic diseases such as congestive heart failure, coronary artery disease, or chronic renal failure,
- •Conditions that may cause physical limitations (e.g., limb amputation, significant musculoskeletal disorders, or postural abnormalities such as kyphosis or lordosis).
研究组 & 干预措施
Control Group
standard aerobic exercise will apply in moderate intensity continuous training.
干预措施: MICT (Other)
interval exercise group
干预措施: HIIT GROUP (Other)
结局指标
主要结局
Peripheral and Respiratory Muscle Oxygenation
时间窗: at the baseline, at the 4th week, at the end of the 8th week.
Muscle oxygenation will be measured using Near-Infrared Spectroscopy from the dominant quadriceps (peripheral) and 7th intercostal space (respiratory) during rest, warm-up, exercise, recovery phases, and 5 minutes post-exercise. Parameters include SmO₂_basal, SmO₂_max, SmO₂_min, SmO₂_maxrec, ∆SmO₂_max, SmO₂_deox, SmO₂_reoxy, and ∆SmO₂_maxrec.
次要结局
- Pulmonary Function test(at the baseline, at the 4th week, at the end of the 8th week.)
- Functional Exercise Capacity(at the baseline, at the 4th week, at the end of the 8th week.)
- Dyspnea(at the baseline, at the 4th week, at the end of the 8th week.)
- Upper extremity Muscle Strength(at the baseline, at the 4th week, at the end of the 8th week.)
- Health-Related Quality of Life(at the baseline, at the 4th week, at the end of the 8th week.)
- Comorbidities(at the baseline, at the 4th week, at the end of the 8th week.)
- Activities of Daily Living(at the baseline, at the 4th week, at the end of the 8th week.)
- lower extremity endurance test(at baseline, at the 4th week and at the end of 8th week.)
研究者
Aynur Demirel
PT, PhD, Assoc. Prof.
Hacettepe University