Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 862
- 试验地点
- 3
- 主要终点
- Prevalence of hypercapnic acute respiratory failure in ICU
研究概览
简要总结
Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases.
Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results.
Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients ≥18 years old presenting with at least of the following items :
- •respiratory rate ≥ 25/min,
- •paradoxical motion of the abdomen,
- •intercostal retraction AND
- •a PaCO2 > 45 cm H20 before ICU admission or within the 12 hours following ICU admission.
排除标准
- •Refusal to give informed consent,
- •pregnancy,
- •< 18 years patient,
- •dying patient
结局指标
主要结局
Prevalence of hypercapnic acute respiratory failure in ICU
时间窗: Intensive Care Unit length stay (Usually 7 days)
Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period
次要结局
未报告次要终点