Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Completed

• Conditions: Intensive Care Unit Syndrome; Hypercapnia; Acute Respiratory Failure

• Registration Number: NCT04304339
• Lead Sponsor: French Society for Intensive Care

Brief Summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases.

Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results.

Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-03-09
• Study First Submitted QC: 2020-03-09
• Study First Posted: 2020-03-11
• Study Start: 2021-12-14
• Primary Completion: 2022-07-13
• Study Completion: 2022-07-13
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-07
• Last Update Posted: 2023-03-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 862

Inclusion Criteria

• patients ≥18 years old presenting with at least of the following items :

  1. respiratory rate ≥ 25/min,
  2. paradoxical motion of the abdomen,
  3. intercostal retraction AND

• a PaCO2 > 45 cm H20 before ICU admission or within the 12 hours following ICU admission.

Exclusion Criteria

• Refusal to give informed consent,
• pregnancy,
• < 18 years patient,
• dying patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of hypercapnic acute respiratory failure in ICU	Intensive Care Unit length stay (Usually 7 days)	Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

Trial Locations

Locations (3)

CHU Nantes; 🇫🇷 Nantes, France

CH Andre Migniot; 🇫🇷 Versailles, A, France

CHU Toulouse; 🇫🇷 Toulouse, France