The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy
- Registration Number
- NCT01451710
- Lead Sponsor
- Nanjing University School of Medicine
- Brief Summary
This is a single center,prospective,no-controlled clinical trial
- Detailed Description
1. The complete remission of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
2. The safety of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Female or male patients aged between 18 to 65 years
- Renal biopsy was used to diagnose IgA nephropathy
- Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L
Exclusion Criteria
- Patients with serum creatinine ≥ 3 mg/dl or eGFR < 30ml/min per 1.73 m2
- urine RBC > 1 million/ml
- Patients who have received treatment of enough steroids for more than 12 weeks
- patients with secondary IgA
- Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis
- Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Prednisone or Prednisolone Prednisone or Prednisolone -
- Primary Outcome Measures
Name Time Method 24h urinary protein excretion 3 months
- Secondary Outcome Measures
Name Time Method remission rate 3 months
Trial Locations
- Locations (1)
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
🇨🇳Nanjing, Jiangsu, China