NCT01451710已完成不适用
The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy
Nanjing University School of Medicine1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2011年3月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 24h urinary protein excretion
研究概览
简要总结
This is a single center,prospective,no-controlled clinical trial
详细描述
- The complete remission of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
- The safety of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Female or male patients aged between 18 to 65 years
- •Renal biopsy was used to diagnose IgA nephropathy
- •Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L
排除标准
- •Patients with serum creatinine ≥ 3 mg/dl or eGFR < 30ml/min per 1.73 m2
- •urine RBC > 1 million/ml
- •Patients who have received treatment of enough steroids for more than 12 weeks
- •patients with secondary IgA
- •Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis
- •Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2
研究组 & 干预措施
Prednisone or Prednisolone
Experimental
干预措施: Prednisone or Prednisolone (Drug)
结局指标
主要结局
24h urinary protein excretion
时间窗: 3 months
次要结局
- remission rate(3 months)
研究者
Zhi-Hong Liu, M.D.
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine
Nanjing University School of Medicine
研究点 (1)
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