Simultaneously PET/MRI in Prolonged DOC Patients
Completed
- Conditions
- Disorder of ConsciousnessFDG-PETMinimally Conscious StateRs-fMRI
- Interventions
- Diagnostic Test: Multimodal Neuroimaging
- Registration Number
- NCT04164680
- Lead Sponsor
- Hangzhou Normal University
- Brief Summary
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- DOC patients （acute, subacute or chronic period）: Coma, UWS and MCS.
Exclusion Criteria
- neuromuscular blocking agents or sedative drugs administered within the prior 24 hours；
- unstable medical condition；
- mental implant in the brain
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with disorders of consciousness Multimodal Neuroimaging -
- Primary Outcome Measures
Name Time Method fludeoxyglucose (FDG-)PET Within 7 days UseFDG-PET to test the metabolism.
resting-state fMRI Within 7 days Use resting-state fMRI to test the functional connectivity
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
International Vegetative State and Consciousness Science Institute, Hangzhou Normal University
🇨🇳Hangzhou, Zhejiang, China