Sonazoid-enhanced Ultrasound for the Detection of Colorectal Liver Metastases Less Than 2 cm
- Conditions
- Liver Metastasis Colon Cancer
- Interventions
- Diagnostic Test: After sonazoid
- Registration Number
- NCT04686942
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
Preoperative chemotherapy is often used for patients with colorectal cancer liver metastasis (CLM). Many small CLMs (\<=2cm) may disappear after chemotherapy, while most of these are still alive. Ultrasonography (US) is a common imaging modality for the intraoperative detection tumor. Sonazoid is new echo-contrast agent, which is more stable and sensitive for detecting of small tumor. Investigators initially this prospective study to compare the detection performance before and after using sonazoid.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 550
Inclusion Criteria
- Pathology confirmed colorectal adenocarcinoma
- One or more liver metastases less than 2 cm
- Multidisciplinary team recommend to perform preoperative chemotherapy
- Have baseline EOB-MR before chemotherapy
Exclusion Criteria
- Could not fulfill the criteria of no evidence of disease (NED) after hepatic resection/ablation/radiotherapy
- With other malignancies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description After sonazoid After sonazoid US detection liver metastases after sonazoid
- Primary Outcome Measures
Name Time Method sensitive of detection tumor 6 months Change of the sensitivity detection liver tumors when using sonazoid enhanced ultrasound
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, China