Single blinded study for the evaluation of bitterness of quinine hydrochloride and loperamide hydrochloride in healthy adult female and male volunteers

Not Applicable

• Conditions: All of diseases that oral medication is prescribed

• Registration Number: JPRN-UMIN000021789
• Lead Sponsor: Intelligent Sensor Technology, Inc.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-04-05
• Study Completion: 2016-05-20
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

1. People who are not like degustation 2. People who are allergic to drugs (quinine hydrochloride, loperamide hydrochloride) 3. people not eligible by the discretion of the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A filter paper wetted with bitter substance will be placed on the tongue of volunteers and the strength of bitterness will be measured within 1 minute. After rinsing thoroughly in the mouth with water, then strengths of bitterness of quinine hydrochloride and loperamide hydrochloride will be measured.

Secondary Outcome Measures

Name	Time	Method
In each volunteer, the concentration of loperamide hydrochloride which produces the same bitterness of quinine hydrochloride at 30 times higher concentration of the threshold value.