Autologous intra-carotid arterial transfusion of peripheral blood stem cells improves brain ischemia and reperfusion in patients with chronic stroke
- Conditions
- Chronic ischemic strokeCirculatory System
- Registration Number
- ISRCTN14654908
- Lead Sponsor
- ational Science Council
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 28
1. Aged between 45 and 80 years
2. Chronic ischemic stroke (onset more than 6 months ago) over middle cerebral artery territory (NIHSS score 9-16)
3. Not suitable for surgery or carotid artery stenting
1. Age less than 45 years old or more than 80 years old
2. Patients received t-PA and anticoagulation
3. Non-middle cerebral artery territory stroke or hemorrhagic stroke
4. Pregnant women
5. Patients with adventitious agents (like HIV virus)
6. Myocardial infarction (MI) within 3 months
7. Severe aortic stenosis or mitral stenosis
8. Congestive heart failure, New York Heart Association functional class (NYHA Fc.)IV
9. Malignancy or other severe disease with life span less than one year
10. Chronic kidney disease with CCr<20ml/min and end stage renal disease
11. Join other clinical trials
12. Patients can not receive regular follow-up
13. Other brain disease (tumor, degenerative disease, infective disease)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method