Effects of intravenous magnesium suphate administration on postoperative analgesia in infraumbilical surgeries under spinal anaesthesia
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To study effect of Intravenous Magnesium Sulphate administration on postoperative ananlgesia in infraumbilical surgeries under spinal anaesthesia
研究概览
简要总结
It is randomized and double blinded prospective study to evaluate the postoperative analgesic effect of Magnesium sulphate by perioperative administration via intravenous route and Intra-operative assessment of HR, BP, Spo2, RR, Input-Output was done. Postoperatively, the patients were assessed using VAS every 4 hours for 24hours. The Heart rate, Blood Pressure and MAP, Respiratory rate and SpO2 were also assessed every 4 hours for 24 hours. The secondary endpoints included assessment of the requirement of rescue analgesia and assessment of hemodynamic effects of magnesium administration in infraumbilical surgeries under spinal anaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18-65years, undergoing lower abdominal surgeries BMI 20-35 kg/m2 ASA Grade I and II Mallampati Score Class I and II Patients giving consent to be part of the study Hemodynamically Stable Patients Routine Investigations (CBC, RFT, LFT, SE)- within normal limits Duration of Surgery less than 4 hours.
排除标准
- •Patients unwilling to Consent Patients with ASA Grade III or IV Hemodynamical Instability (Hypotension, Bradycardia) Severe or Uncontrolled Diabetes or Hypertension, CVD Cardiovasular Disease (CAD, HF, Cardiomyopathies, Valvular Heart Diseases) Hepatic Impairment, Renal Impairment Known case of Coagulopathies, abnormal hemoglobin, Anaemia Known case of Kyphoscoliosis and deformity of spine.
结局指标
主要结局
To study effect of Intravenous Magnesium Sulphate administration on postoperative ananlgesia in infraumbilical surgeries under spinal anaesthesia
时间窗: After administration of the spinal anaesthesia, comparison between the two groups of onset and duration of sensory and motor blockade, duration of analgesia and time of rescue of analgesia will be assessed at baseline, after injection of study drug at immediate postop, 15mins, 30mins, 45mins, 60minms, 4hrs, 8hrs, 12hrs, 16hrs, 20hrs, 24hrs and assessment VAS score
次要结局
- To study effect of Intravenous Magnesium Sulphate administration on postoperative ananlgesia in infraumbilical surgeries under spinal anaesthesia(Duration of analgesia will be assessed post surgery after administration of magnesium sulphate & time of rescue analgesia will be assessed)
研究者
Dr Subhashree Jena
Dr D.Y. Patil Medical College, Hospital and Research Centre