Surgical outcomes following breast reconstruction in patients with and without a history of chest radiotherapy for Hodgkin lymphoma: a multicenter, matched cohort study

• Conditions: Z42.1; C81; Follow-up care involving plastic surgery of breast; Hodgkin lymphoma

• Registration Number: DRKS00028655
• Lead Sponsor: Department of Plastic and Reconstructive Surgery, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-15
• Study Completion: 2022-07-15
• Results First Posted: 2023-04-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 191

Inclusion Criteria

Group 1:
Breast reconstructions in Hodgkin survivors diagnosed with BC after previous chest radiotherapy for Hodgkin and who had undergone BR after therapeutic or prophylactic mastectomy.

Group 2:
Control breast reconstructions after therapeutic or prophylactic mastectomy in patients without a history of HL or chest radiotherapy were matched to patients in group 1 on age at mastectomy (±five years), date of BR (±five years), and type of BR (direct-to-implant; tissue expander/implant; autologous with implant; autologous only) and timing of BR (immediate or delayed).

Exclusion Criteria

Breasts which had received radiotherapy for BC before BR were excluded. Patients were excluded if their electronic health records had missing data regarding supradiaphragmatic radiotherapy.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
complication-related breast reconstruction failure or conversion

Secondary Outcome Measures

Name	Time	Method
complication-related re-operation, capsular contracture, major donor-site complications, and complication-related ICU admission