Study on Therapeutic Mechanism of Natural Psychotherapy for Neurosis
- Conditions
- Obsessive-Compulsive Disorder
- Interventions
- Other: Natural psychotherapy
- Registration Number
- NCT06443125
- Lead Sponsor
- Xiang Yang Zhang
- Brief Summary
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
- Detailed Description
1. To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population.
2. Investigate the pathological mechanism of neurotic patients from the aspects of electroencephalic graph/functional magnetic resonance imaging (EEG/fMRI) and biology.
3. To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Have a diagnosis of obsessive-compulsive disorder or compulsive behavior
- Duration of symptoms for not less than 12 months
- Age 15-60 years old.
- You can participate in the whole experiment and offline assessment in Beijing
- Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma
- Subjects who suffered from alcohol or illegal drug abuse/dependence
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Natural Psychotherapy intervention for obsessive-compulsive disorder Natural psychotherapy Inpatient naturopathic treatment was performed once a day for 45 consecutive days
- Primary Outcome Measures
Name Time Method Mood and behavior Baseline, 12 weeks Mood changes judged using gait and face recognition
Cognitive function Baseline, 12 weeks Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.
ERP components associated with cognitive function Baseline, 12 weeks To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis
Obsessive-compulsive symptoms Baseline, 12 weeks Obsessive-compulsive symptoms were assessed according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), The total score ranges from 0 to 40, with higher scores indicating more severe symptoms.
rest fMRI in Obsessive-compulsive patients Baseline, 12 weeks The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.
Behavioral inhibition Baseline, 12 weeks behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Anhui Mental Health Center
🇨🇳Hefei, Anhui, China
Institute of Psychology, Chinese Academy of Sciences
🇨🇳Beijing, China