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Effect of Appropriate Dose, Spectrum, and Timing of Antibiotics on 28-day Mortality in Patients with Sepsis in the Emergency Department

Completed
Conditions
Effect of Appropriate Dose, Spectrum, and Timing of Antibiotics on 28-day Mortality in Patients with Sepsis in the Emergency Department
Appropriate antibiotics, timing, dose, spectrum, sepsis, 28-day mortality, emergency department
Registration Number
TCTR20211216003
Lead Sponsor
no
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
All
Target Recruitment
593
Inclusion Criteria

1) aged >15 years; 2) diagnosed with sepsis according to the ICD-10 or by an attending physician or according to the results of blood culture, body fluid culture, or specimen culture; and 3) patients in the ED in whom the Ramathibodi sepsis protocol had been followed

Exclusion Criteria

1) patients who had received oral antibiotics within the past 7 days, 2) patients with cardiac arrest before arrival in the ED or with a do-not-resuscitate order signed on the day of arrival in the ED; 3) patients with a definite diagnosis unrelated to sepsis; 4) patients who were transferred out of the ED within 24 hours; 5) patients referred in from other hospitals, and 6) patients with missing data in the Ramathibodi Hospital database and emergency medical record.

Study & Design

Study Type
Observational
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
28 day mortality day 28 death at day 28
Secondary Outcome Measures
NameTimeMethod
In-hospital mortality time to disposition from hospital hospital death,28-day ventilator- free days day 28 day alive without ventilator in 28 day,28-day hospital- free days day 28 day alive without hospital in 28 day
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