Effect of Appropriate Dose, Spectrum, and Timing of Antibiotics on 28-day Mortality in Patients with Sepsis in the Emergency Department
- Conditions
- Effect of Appropriate Dose, Spectrum, and Timing of Antibiotics on 28-day Mortality in Patients with Sepsis in the Emergency DepartmentAppropriate antibiotics, timing, dose, spectrum, sepsis, 28-day mortality, emergency department
- Registration Number
- TCTR20211216003
- Lead Sponsor
- no
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 593
1) aged >15 years; 2) diagnosed with sepsis according to the ICD-10 or by an attending physician or according to the results of blood culture, body fluid culture, or specimen culture; and 3) patients in the ED in whom the Ramathibodi sepsis protocol had been followed
1) patients who had received oral antibiotics within the past 7 days, 2) patients with cardiac arrest before arrival in the ED or with a do-not-resuscitate order signed on the day of arrival in the ED; 3) patients with a definite diagnosis unrelated to sepsis; 4) patients who were transferred out of the ED within 24 hours; 5) patients referred in from other hospitals, and 6) patients with missing data in the Ramathibodi Hospital database and emergency medical record.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 28 day mortality day 28 death at day 28
- Secondary Outcome Measures
Name Time Method In-hospital mortality time to disposition from hospital hospital death,28-day ventilator- free days day 28 day alive without ventilator in 28 day,28-day hospital- free days day 28 day alive without hospital in 28 day