NCT04445506已完成不适用
The Effect of the Short-term Use of Systemic Corticosteroids in COVID-19 Patients in Regard to Hospital Length of Stay, Morbidly and/or Mortality.
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Effect on transfers to ICU and escalation of care needing mechanical ventilation
研究概览
简要总结
The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Moderate disease with at least a 30% increase in CRP within 36 hours of admission, and with increasing oxygen requirements.
- •All patients with severe disease with evidence of escalating oxygen requirements
- •The presence of secondary bacterial infections as a probable cause of increasing CRP levels was excluded in all selected patients.
- •Pulmonary embolism and /or cardiac dysfunction were excluded as probable causes of worsening hypoxia in all selected patients.
排除标准
- •All patients on other treatment modalities- Remdesivir and/or Convalescent plasma who showed evidence of clinical improvement as per decrease in CRP levels and/or oxygen requirements were excluded.
- •Patient with associated COPD exacerbation who would benefit from the use of steroids.
- •Patients with Diabetic ketoacidosis, hyperglycemic hyperosmolar state, active concurrent bacterial infections.
- •Patients with history of steroid-induced mania and/or psychosis.
研究组 & 干预措施
SARS-CoV2 patients that received dexamethasone
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Effect on transfers to ICU and escalation of care needing mechanical ventilation
时间窗: 2 months
次要结局
- Effect on length of stay(2 months)
- Change in CRP levels(2 months)
研究者
研究点 (1)
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