Short Term Corticosteroids in SARS-CoV2 Patients

Completed

• Conditions: Corticosteroids; Covid19; SARS-CoV 2; Steroids; Dexamethasone
• Interventions: Drug: Dexamethasone

• Registration Number: NCT04445506
• Lead Sponsor: The Miriam Hospital

Brief Summary

The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-01
• Status Verified: 2020-05
• Primary Completion: 2020-05-31
• Study Completion: 2020-05-31
• Study First Submitted: 2020-06-19
• Study First Submitted QC: 2020-06-22
• Last Update Submitted: 2020-06-22
• Study First Posted: 2020-06-24
• Last Update Posted: 2020-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Moderate disease with at least a 30% increase in CRP within 36 hours of admission, and with increasing oxygen requirements.
2. All patients with severe disease with evidence of escalating oxygen requirements
3. The presence of secondary bacterial infections as a probable cause of increasing CRP levels was excluded in all selected patients.
4. Pulmonary embolism and /or cardiac dysfunction were excluded as probable causes of worsening hypoxia in all selected patients.

Exclusion Criteria

1. All patients on other treatment modalities- Remdesivir and/or Convalescent plasma who showed evidence of clinical improvement as per decrease in CRP levels and/or oxygen requirements were excluded.
2. Patient with associated COPD exacerbation who would benefit from the use of steroids.
3. Patients with Diabetic ketoacidosis, hyperglycemic hyperosmolar state, active concurrent bacterial infections.
4. Patients with history of steroid-induced mania and/or psychosis.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
SARS-CoV2 patients that received dexamethasone	Dexamethasone	-

Primary Outcome Measures

Name	Time	Method
Effect on transfers to ICU and escalation of care needing mechanical ventilation	2 months

Secondary Outcome Measures

Name	Time	Method
Effect on length of stay	2 months
Change in CRP levels	2 months

Trial Locations

Locations (1)

The Miriam Hospital; 🇺🇸 Providence, Rhode Island, United States