TO QUANTIFY AND COMPARE THE LEVELS OF miRNA 155 IN HEALTHY AND DISEASED GINGIVAL TISSUES AND ITS EFFECT ON BONE RESORBING CELLS.

Not Applicable

• Conditions: Health Condition 1: K053- Chronic periodontitis

• Registration Number: CTRI/2021/04/032800
• Lead Sponsor: SOWMYA REDDY

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

INCLUSION CRITERIA FOR PERIODONTALLY DISEASES GINGIVAL TISSUES

1)Patients with age group >= 18years

2)Patients with Stage III Periodontitis and Stage IV Periodontitis (according to 2017 EPF/AAP Classification)

3)Gingival Index >= 1

4)Periodontal Probing depth >= 6mm

5)Clinical Attachment Loss >= 3mm

6)Radiographic evidence of bone loss >= 50%

EXCLUSION CRITERIA

1)Diabetic Patients

2)Patients with any other systemic diseases/ auto immune diseases

3)Patients under medication with immuno suppressants, antibiotics, anti-inflammatory drugs in the last six months

4)Pregnant or lactating mothers.

5)Smokers ( current and past)

6)Previous history of periodontal therapy

Exclusion Criteria

1)Diabetic patients

2)Patients with any other systemic diseases/ auto immune diseases

3)Patients under medication with immuno suppressants, antibiotics, anti inflammatory drugs in the last 6months,

4)Pregnant or lactating mothers,

5)smokers

6) previous history of periodontal therapy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)quantify and compare the expression of miRNA 155 in periodontal disease and healthy gingival tissues <br/ ><br>2)To quantify and compare the expression of Micropthalmia Induced Transcription Factor (MITF) in periodontal disease and healthy gingival tissues <br/ ><br> <br/ ><br>Timepoint: at baseline

Secondary Outcome Measures

Name	Time	Method
1. To compare and correlate the miR-155 levels and Micropthalmia Induced Transcription Factor levels in periodontal disease and healthy gingival tissues <br/ ><br> <br/ ><br>2. To compare and correlate the miR-155 levels and Micropthalmia Induced Transcription Factor levels in periodontal disease and healthy gingival tissues with the clinical parameters <br/ ><br>Timepoint: at baseline