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Clinical Trials/NCT06587607
NCT06587607
Recruiting
Not Applicable

Exploring Virtual Reality Mindfulness Training for Veterans With SCI and Chronic Pain

VA Office of Research and Development1 site in 1 country10 target enrollmentJuly 1, 2025

Overview

Phase
Not Applicable
Intervention
VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.
Conditions
Spinal Cord Injury
Sponsor
VA Office of Research and Development
Enrollment
10
Locations
1
Primary Endpoint
Mindfulness- Five Facet Mindfulness Questionnaire (FFMQ)
Status
Recruiting
Last Updated
2 months ago

Overview

Brief Summary

This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA CALM program more accessible for those with SCI. It will involve delivering the unmodified curriculum to a group of Veterans with SCI first to determine what areas need accommodations, working with a group of stakeholders to develop appropriate accommodations, and then delivering 1-2 modified modules via virtual reality to evaluate whether using virtual reality was feasible and acceptable for this program.

Detailed Description

The objectives of this study are to explore the feasibility and acceptability of a spinal cord injury (SCI) tailored, evidence-based mindfulness group known as VA Compassionate Awareness Learning Module (VA CALM) when delivered via virtual reality (VR) The project will first assess modification needs for SCI and then explore the feasibility and acceptability of delivering VA CALM-SCI over VR. The long-term goals and significance of this study include studying the efficacy of VA CALM-SCI for the treatment of chronic pain and examining the comparative effectiveness between VR and video telehealth modalities to build evidence for the modified intervention. This work has the potential to improve care for Veterans with SCI who are at risk of being left out of innovative clinical advancements that improve quality of life and well-being, due to the complexity of their medical condition. Aim 1: Conduct a formative evaluation of the VA CALM program to develop accommodations to improve program accessibility and acceptability for Veterans with SCI and chronic pain (VA CALM-SCI). * Aim 1a: Deliver the VA CALM program to 10 Veterans with SCI over telehealth to conduct a formative evaluation of the VA CALM curriculum to tailor for SCI contextual needs. * Aim 1b: Assemble a Steering Committee of SCI stakeholders (10 members) to develop appropriate strategies, accommodations, and recommended tools to support the delivery of VA CALM-SCI. Aim 2: Explore the feasibility and acceptability of delivering VA CALM-SCI over a Virtual Reality platform for Veterans with SCI and chronic pain. * Aim 2a: Assess potential VR applications and settings for delivery and testing of VA CALM-SCI. * Aim 2b: Deliver 2 VA CALM-SCI modules over VR to Veterans with SCI to assess the feasibility and acceptability of using VR in this population to deliver mindfulness training.

Registry
clinicaltrials.gov
Start Date
July 1, 2025
End Date
June 30, 2027
Last Updated
2 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of spinal cord injury with incomplete or complete tetraplegia based on AIS score OR incomplete or complete paraplegia based on AIS score.
  • Endorses chronic pain lasting 3 months;
  • age 18+ years
  • Access to high-speed internet
  • Endorse being (at least) minimally proficient on the computer (eg, able to check emails, read the news, etc.); be able, either independently or with caregiver support, to get online for virtual meetings and don/doff VR equipment
  • Able to speak clearly and independently to participate in focus group interviews.

Exclusion Criteria

  • Individuals unable to consent for research or medical care are ineligible to participate.

Arms & Interventions

VA CALM

This group will receive the VA CALM mindfulness programming.

Intervention: VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.

Outcomes

Primary Outcomes

Mindfulness- Five Facet Mindfulness Questionnaire (FFMQ)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 1 Maximum Score: 5 Score Interpretation: Items are aggregated and averaged. Higher scores indicate greater mindfulness.

Pain- PROMIS-Pain Numeric Rating Scale (NRS)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 0 Maximum Score: 10 Score Interpretation: Single item measure, higher scores indicate greater pain intensity.

Mindfulness- Mindfulness Attention Awareness Scale (MAAS)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 1 Maximum Score: 6 Score Interpretation: Items are aggregated and averaged. Higher scores indicate greater mindfulness

Pain Interference- PROMIS-Pain Interference (PROMIS-PI, SF8a)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 8 Maximum Score: 40 Score Interpretation: Scores are converted into a T-score which rescales the score into a standardized score with a mean of 50 and a standard deviation of 10. Higher scores indicate greater pain interference.

Pain Acceptance- Chronic Pain Acceptance Questionnaire-Revised (CPAQ-R)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 0 Maximum Score: 6 Score Interpretation: Generates scores for two domains: Activity Engagement and Pain Willingness. Scores for each item in a domain are aggregated. Higher scores indicate higher levels of acceptance.

Pain Catastrophizing- Pain Catastrophizing Scale (PCS)

Time Frame: Baseline to 2 weeks post completion (Approx 14 weeks).

Minimum Score: 0 Maximum Score: 52 Score Interpretation: Generates a total score PCS-T and three subscale scores: Rumination, Magnification, and Helplessness. Total score above 30 indicates clinically relevant level of catastrophizing.

Secondary Outcomes

  • Quality of Life- World Health Organization Quality of Life-Brief (WHOQOL-BREF)(Baseline to 2 weeks post completion (Approx 14 weeks).)
  • Anxiety- Generalized Anxiety Disorder (GAD-7)(Baseline to 2 weeks post completion (Approx 14 weeks).)
  • Depression- Patient Health Questionnaire-9 (PHQ-9)(Baseline to 2 weeks post completion (Approx 14 weeks).)
  • Virtual Reality Embodiment- One-Item Presence Scale(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)
  • Virtual Reality Embodiment- Virtual Embodiment Questionnaire(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)
  • Acceptability of Virtual Reality- System Usability Scale (SUS)(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)
  • Acceptability of Virtual Reality- Standardized User Experience Percentile Rank Questionnaire (SUPRQ)(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)
  • Acceptability of Program- Acceptability of Intervention Measure (AIM)(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)
  • Acceptability of Program- Intervention Appropriateness Measure (IAM)(After completion of 2nd VR session (One time point at completion of study, approximately week 12).)

Study Sites (1)

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