Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Average daytime systolic blood pressure
研究概览
简要总结
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is:
• When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours?
Participants will:
-
Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night
-
Complete 3 supervised treadmill exercise sessions
-
1 in the biological morning (biological night + 10 hours)
-
1 in the biological afternoon (biological night + 15 hours)
-
1 in the biological evening (biological night + 20 hours)
-
Complete a 24-hour blood pressure assessment before and after each exercise session
详细描述
This fully counterbalanced, within-subject, randomized crossover trial will examine the time-of-day dependent hypotensive effect of exercise in adults aged 18-39 years with elevated blood pressure or stage 1 hypertension. To examine this, participants will complete an assessment of dim-light melatonin onset (DLMO), the gold standard assessment of individual circadian phase, which will be used to subsequently prescribe three exercise sessions in the morning (10 hours after DLMO), afternoon (15 hours after DLMO), and evening (20 hours after DLMO) with 24-hour blood pressure assessment before and after each exercise sessions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-39 Years old
- •Resting blood pressure greater than or equal to 120/80 mmHg or less than 140/90 mmHg
排除标准
- •Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)
- •Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)
- •Alcohol or drug dependence
- •Elevated risk for sleep disorders
- •Elevated risk for clinical depression
- •Normotensive (blood pressure less than 120/80 mmHg) or stage 2+ hypertension (blood pressure greater than or equal to 140/90 mmHg)
- •Body mass index less than 18.5 or greater than 35 kg/m2
- •Self-reported use of sleep medications/supplements (e.g., melatonin)
- •Self-reported use of medications influencing vascular physiology (e.g., antihypertensive medications, weight loss medications)
- •Highly physically active (greater than or equal to 300 minutes moderate-to-vigorous physical activity per week)
- •Currently pregnant or breastfeeding
- •Current tobacco use (greater than or equal to 1 cigarette in the past month)
- •Nighttime or rotating shift work within the last 3 months
- •Contraindications to aerobic exercise
研究组 & 干预措施
Afternoon
Exercise 15 hours after dim-light melatonin onset
干预措施: Exercise (Behavioral)
Morning
Exercise 10 hours after dim-light melatonin onset
干预措施: Exercise (Behavioral)
Evening
Exercise 20 hours after dim-light melatonin onset
干预措施: Exercise (Behavioral)
结局指标
主要结局
Average daytime systolic blood pressure
时间窗: 24-hours
Change in average daytime systolic blood pressure (post-exercise - pre-exercise)
次要结局
未报告次要终点
研究者
Freda Patterson
Professor
University of Delaware