Breakfast Consumption and Its Effects on Glycemic, Insulinemic and Non-Esterified Fatty Acids Responses
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Glycemic response
研究概览
简要总结
The aim of this study is to determine whether eating breakfast or having no breakfast has subsequent beneficial health effects, specifically in relation to glycemic response throughout the day and postprandial insulin and non-esterified fatty acids (NEFA) responses 6 hours after breakfast/lunch.
详细描述
This will be a randomised, crossover study with two treatments in total. 1.) Subjects given with breakfast, 2.) Subjects not given breakfast. Each of the two test visits will last for approximately 9 hour (spanning over 3 days), during which the following will take place: On Day 1, subjects will come to have the continuous glucose monitoring (CGMS) system inserted. CGMS will be used to measure 24 hour blood glucose concentrations. On Day 2, an indwelling catheter will be inserted into the ante cubital fossa or forearm vein of one arm and will be kept patent. One fasting blood sample (baseline; 4 milliliters of venous blood) will be collected. Participants with breakfast treatment will then consume the test meal within 15 minutes. Subsequently, blood samples will be taken at 15, 30, 45, 60, 90, 120, 150 and 180 minutes.At time 180 minutes, participants will be given a standardized lunch to be consumed within 30 minutes. Blood samples will be taken after lunch at 210, 240, 270, 300, 330 and 360 minutes. On Day 3, subjects will need to come for removal of the CGMS sensor. Subjects will come to the CNRC again for the 2nd test visit, with at least 3 days wash-out in-between visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Chinese males
- •BMI above 23.0 kg/m2
- •Age between 40-65 years
- •Normal blood pressure (<140/90 mmHg)
- •Fasting blood glucose of ≥5.6 mmol/L
- •Self-reported regular breakfast consumers
排除标准
- •Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
- •major chronic disease such as heart disease, cancer or diabetes mellitus
- •taking insulin or drugs known to affect glucose metabolism
- •Intentionally restrict food intake
- •major medical or surgical event requiring hospitalization within the preceding 3 months
- •Have taken antibiotics for 3 months before the study period
- •Overnight shift workers
- •Any known food allergy (eg. anaphylaxis to peanuts)
- •Having active Tuberculosis (TB) or currently receiving treatment for TB
- •Any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- •Being a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- •Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC.
研究组 & 干预措施
Breakfast
Subject given standardized breakfast (glutinous rice) to test blood glucose response
干预措施: Breakfast (Other)
No breakfast
Subject not given breakfast to test blood glucose response
干预措施: No Breakfast (Other)
结局指标
主要结局
Glycemic response
时间窗: 1.5 days
Using continuous glucose monitoring system
Insulin response
时间窗: 6 hours
Postprandial after treatment
Non-esterified fatty acids (NEFA) response
时间窗: 6 hours
Postprandial after treatment
次要结局
未报告次要终点
研究者
JeyaKumar Henry
Principal Investigator
Clinical Nutrition Research Centre, Singapore