The Effect of Applying Modified NUTRIC Scoring System to Evaluate the Nutrition Risk and Giving Different Types of Nutritional Support on Clinical Outcomes in Critically Ill Patients

Not Applicable

• Conditions: Critical Illness
• Interventions: Dietary Supplement: Trophic feeding; Dietary Supplement: volume-based feeding

• Registration Number: NCT03365258
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

Malnutrition is very common in critically ill patients. It is quite important to evaluate nutritional status precisely. Heyland et al firstly reported NUTRIC score including age, APACHE II score, SOFA score, number of commorbidities, days from hospital to ICU admission and IL-6. Because the IL-6 is not routinely checked at ICU. A modified NUTRIC score without IL-6 is more practical. Previous studies showed lower in-hospital mortality in higher nutritional risk patients with higher caloric intake compared with lower caloric intake. However, there is still controversial regarding the in-hospital mortality between full caloric feeding and permissive underfeeding in critically ill patients. Herein the investigators conduct a study to investigate what kinds of nutritional supplements will decrease in-hospital mortality in different nutritional risk patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-11-28
• Study First Submitted QC: 2017-12-02
• Study First Posted: 2017-12-07
• Study Start: 2017-12-28
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-05
• Last Update Posted: 2020-02-07
• Primary Completion: 2020-05-31
• Study Completion: 2020-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• 1. Medical intensive care unit patients 2. age elder than 20 years old 3. Intubated with ventilator support patients 4. Predicted ICU stay longer than 72 hours

Exclusion Criteria

• 1. NPO patients 2. Contraindication for enteral feeding 3. TPN use 4. Upper or lower GI bleeding patients 5. Feeding with gastrostomy or Jejunostomy patients 6. Metoclopramide related EPS or Torsades de pointes history

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low Nutritional Risk	volume-based feeding	modified NUTRIC score \< 5
Low Nutritional Risk	Trophic feeding	modified NUTRIC score \< 5
High Nutritional Risk	Trophic feeding	modified NUTRIC score ≥ 5
High Nutritional Risk	volume-based feeding	modified NUTRIC score ≥ 5

Primary Outcome Measures

Name	Time	Method
In-hospital mortality	90 days	mortality or discharge

Trial Locations

Locations (1)

王振宇; 🇨🇳 Taichung City, 台中市, Taiwan