Evaluation of safety and effect of Anethum graveolens Linn. (Dill) extract beverage against stress in working age volunteers
Phase 1
Completed
- Conditions
- Healthy ConditionsAnethum graveolensDillcognitive processingstressworking memory
- Registration Number
- TCTR20210407002
- Lead Sponsor
- Program Management Unit Competitiveness (PMUC)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1.Aged between 20 -55 years old
2.Body Mass Index (BMI) 18.5-25 kg/m2
3.DASS-21 score more than 10
Exclusion Criteria
1.Volunteers who have been diagnosed with one of the following; diabetes mellitus, cardiovascular diseases, liver disease, kidney disease, respiratory diseases, autoimmune disease and neuropsychological diseases
2.Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor before trial
3.Volunteers who use hormone or any drug that effect on the nervous system during 3 month before the test
4.Smoking more than 10 pieces/ day
5.Drinking alcohol more than 5 times/ day
6.Volunteers who participate in other projects
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression Anxiety Stress Scale 21 Thai 6 weeks DASS-21 Thai questionnaire
- Secondary Outcome Measures
Name Time Method The changes of hematological and clinical chemistry parameters 6 weeks laboratory,Acetylcholinesterase (AChE), Monoamine oxidase (MAO), Monoamine oxidase type A (MAO-A) and GABA-T 6 weeks laboratory,Oxidative stress markers; Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) 6 weeks laboratory,Inflammatory markers (IL-6, CRP) 6 weeks ELISA method,Physical fitness 6 weeks equipment,Evaluation of sleep quality 6 weeks Thai version of the Pittsburgh Sleep Quality Index, T - PSQI,Evaluation of Mood 6 weeks MOSAIC questionnaire,N100 and P300 6 weeks Event related evoked potentials (ERPs),Working memory test 6 weeks Computerized batteries test ,The changes of electrocardiogram 6 weeks Electrocardiography