Efficacy of Genicular Block on Total Knee Arthroplasty Surgery

Not Applicable

Not yet recruiting

• Conditions: Total Knee Anthroplasty; Genicular Nerves Block
• Interventions: Drug: Genicular blocks (bupivakain); Drug: Patient Control Analgesia (PCA) Morphine group; Drug: Paracetamol (acetaminophen) + Diclofenac Sodium

• Registration Number: NCT06942702
• Lead Sponsor: Mersin University

Brief Summary

The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?

2. Does opioid consumption decrease in patients who underwent geniculate block?

Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.

Detailed Description

Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery without the administration of general anesthesia, while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.

Study Timeline

• Status Verified: 2025-04
• Study First Submitted: 2025-04-17
• Study First Submitted QC: 2025-04-17
• Study First Posted: 2025-04-24
• Last Update Submitted: 2025-04-24
• Last Update Posted: 2025-04-29
• Study Start: 2025-05-20
• Primary Completion: 2025-10-20
• Study Completion: 2025-12-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Scheduled for unilateral and primary total knee arthroplasty
• Older than 18 years of age

Exclusion Criteria

• Younger than 18 years
• Bilateral knee arthroplasty
• Revision case of knee arthroplasty

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Genicular block group	Genicular blocks (bupivakain)	this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)
Genicular block group	Patient Control Analgesia (PCA) Morphine group	this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)
Genicular block group	Paracetamol (acetaminophen) + Diclofenac Sodium	this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)
patients only given PCA-morfin postoperatively	Patient Control Analgesia (PCA) Morphine group	this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed)
patients only given PCA-morfin postoperatively	Paracetamol (acetaminophen) + Diclofenac Sodium	this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed)

Primary Outcome Measures

Name	Time	Method
Visual Analog Scale Measure	0-48 hours	VAS scores are assessed at 0th, 24th and 48th hours post operatively VAS score consists of 0-10 in numbers, the bigger the number the worse the pain
opioid consumption	0-48 hours	Morphine consumption is assesed by PCA