ate term complications after radiotherapy of the neck; Cognitive functioning and gait.

Completed

• Conditions: Stroke; vascular injury; 10007963

• Registration Number: NL-OMON36964
• Lead Sponsor: eurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 76

Inclusion Criteria

RT of the neck because of a T1/T2 (N0M0) laryngeal carcinoma, T1/T2 (N0M0) parotid carcinoma / pleomorphic adenoma, T1/2 (N1/2M0) oro/hypopharynxcarcinoma or non-Hodgkin/Hodgkin lymphoma and a minimal follow-up of 6 years post RT.

Exclusion Criteria

History of cerebrovascular disease, pregnancy or breast-feeding, ongoing treatment with an HMG-coA reductase or cytochroom P450 inhibitor, active liver disease or > 3 times the upper limit of serum transaminases, 5 times the normal level of creatine phosphokinase, serum cholesterol > 7 mmol/L and a life expectancy < 2 years. Contra-indication for (contrast enhanced) MRI/A.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Incidence, location and composition of extra- and intracranial postirradiation<br /><br>vessel wall assessed by MRI/A and duplexultrasonography.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Incidenc of white matter lesions, (silent) brain infarctions and atrophy,<br /><br>assessed bij MRI/A<br /><br>- Incidence cardio and cerebrovascular diseases<br /><br>- Scores on balans and gaith parameters<br /><br>- Incidence cognitive dysfunctioning, assessed by a neuropsychological<br /><br>excamination </p><br>