A Randomized Controlled Trial to Compare Fertilizations With Immotile Sperm After Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Clinical pregnancy
研究概览
简要总结
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Women up to 35 years of age
- •immotile sperm
- •At least 6 mature eggs
排除标准
- •globozoospermia
- •"Freeze all" cycles because of OHSS risk.
研究组 & 干预措施
PXN only
Sperm activation with PXN before ICSI
干预措施: PXN sperm treatment (Biological)
PXN activation and oocyte activation
Sperm activation with PXN and oocyte activation
干预措施: Sperm activation with PXN and oocyte activation (Biological)
结局指标
主要结局
Clinical pregnancy
时间窗: One month post oocyte retrieval
Demonstration of fetal heart activity 1 month post oocyte retrieval.
次要结局
- Fertilization rate(One day post oocyte retrieval)
研究者
Shahar Kol MD
Durector, IVF Unit
Rambam Health Care Campus