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Clinical Trials/NCT02051075
NCT02051075
Withdrawn
Phase 4

A Randomized Controlled Trial to Compare Fertilizations With Immotile Sperm After Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation

Rambam Health Care Campus1 site in 1 countryMarch 2014
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ConditionsInfertility

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Infertility
Sponsor
Rambam Health Care Campus
Locations
1
Primary Endpoint
Clinical pregnancy
Status
Withdrawn
Last Updated
10 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.

Registry
clinicaltrials.gov
Start Date
March 2014
End Date
May 2015
Last Updated
10 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Shahar Kol MD

Durector, IVF Unit

Rambam Health Care Campus

Eligibility Criteria

Inclusion Criteria

  • •Women up to 35 years of age
  • •immotile sperm
  • •At least 6 mature eggs

Exclusion Criteria

  • •globozoospermia
  • •"Freeze all" cycles because of OHSS risk.

Outcomes

Primary Outcomes

Clinical pregnancy

Time Frame: One month post oocyte retrieval

Demonstration of fetal heart activity 1 month post oocyte retrieval.

Secondary Outcomes

  • Fertilization rate(One day post oocyte retrieval)

Study Sites (1)

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