Analysis of Preoxygenation Combining Nasal Cannula With Noninvasive Positive Pressure Ventilation: A Randomized Crossover Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- End-tidal Oxygen
研究概览
简要总结
This is a prospective randomized cross over study of healthy volunteers comparing end-tidal oxygen concentration among subjects undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (NIV) mask with and without the addition of nasal cannulas.
详细描述
Noninvasive positive pressure ventilation with the addition of a nasal cannula is a useful technique to pre-oxygenate and provide apneic oxygenation in hypoxic patients undergoing emergency airway management. This study aims to evaluate preoxygenation by quantifying end-tidal oxygen (etO2) concentration resulting from nasal cannula placement underneath a noninvasive positive pressure ventilation (NIPPV) mask. This is a prospective randomized cross over study of healthy volunteers undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (NIV) mask with and without the addition of nasal cannulas. End-tidal oxygen concentration will be measured by an oxygen sensor following three minutes of NIPPV with and without the addition of a nasal cannula, with each subject serving as his or her own control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any healthy volunteer aged 18-65 years.
排除标准
- •Previous inability to tolerate noninvasive positive pressure ventilation with addition of a nasal cannula.
- •Known underlying cardiac or pulmonary disease.
- •Active respiratory infections.
研究组 & 干预措施
Ventilation with nasal cannula
Non-invasive positive pressure ventilation with nasal cannula.
干预措施: Ventilation with nasal cannula (Device)
Ventilation with nasal cannula
Non-invasive positive pressure ventilation with nasal cannula.
干预措施: Ventilation without nasal cannula (Device)
Ventilation without nasal cannula
Non-invasive positive pressure ventilation without nasal cannula.
干预措施: Ventilation with nasal cannula (Device)
Ventilation without nasal cannula
Non-invasive positive pressure ventilation without nasal cannula.
干预措施: Ventilation without nasal cannula (Device)
结局指标
主要结局
End-tidal Oxygen
时间窗: 3 minutes after study start
Measured by exhalation into sensor (Maxtec Max-250E)
次要结局
未报告次要终点
研究者
Michael D. April
Assistant Program Director for Research, Emergency Medicine
Brooke Army Medical Center