Additional Effects of Perioperative Immunonutrition on Th1/Th2 Differentiation in Patients Undergoing Pancreaticoduodenectomy
试验速览
- 阶段
- 4 期
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- plasma resolvin E1, cell-mediated immunity
研究概览
简要总结
The purpose of this study is to investigate whether perioperative immunonutrition has additional effects on cell-mediated immunity in patients undergoing pancreaticoduodenectomy.
详细描述
The investigators reported that perioperative immunonutrition had no additional effects compared with preoperative immunonutrition in patients underwent colorectal surgery (Braga M, Gianotti L, Vignali A, Carlo VD. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery. 2002; 132:805-14, PMID: 12464864). Object of this study is to investigate the additional effects of perioperative immunonutrition on cell-mediated immunity and incidence of infectious complication after pancreaticoduodenectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing pancreaticoduodenectomy
排除标准
- •age younger than 18 years old
- •ongoing infection
- •gastrointestinal obstruction
- •respiratory dysfunction
- •cardiac dysfunction
- •hepatic dysfunction
- •renal failure
- •history of recent immunosuppressive or immunological disease
- •preoperative evidence of widespread metastatic disease
结局指标
主要结局
plasma resolvin E1, cell-mediated immunity
时间窗: 30 days
次要结局
- infectious complication rate(30 days)
研究者
Katsunori Furukawa
MD, PhD
Chiba University