Food Reward in Cachexia Induced by Acute or Chronic Disease
Terminated
- Conditions
- Chronic Obstructive Pulmonary DiseaseCachexiaNon-small Cell Lung CancerPancreatic Cancer
- Interventions
- Other: Functional magnetic resonance imaging (fMRI)
- Registration Number
- NCT02798003
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.
- Detailed Description
The activity in the food reward-circuitry of the brain in patients suffering from cachexia induced by cancer (lung cancer or pancreatic cancer) or chronic disease (chronic obstructive pulmonary disease) will be analysed by using functional magnetic resonance imaging. In addition, the role of the peripheral satiety hormones will be evaluated.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
- For cachectic patients: weight loss exceeds 5% of total body weight over the past 6 months, or >2% when body mass index is <20 kg/m2
- For non-cachectic patients: no weight loss of ≥5% during the last 6 months
- Non-small cell lung cancer or gastro-intestinal cancer, pathology proven or diagnosis of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria
Exclusion Criteria
- Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; Pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up)
- Psychiatric or other disorders likely to impact on informed consent
- Presence of brain metastasis (screening is not mandatory)
- Medical history of cerebrovascular accident, brain tumour, brain metastasis
- Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy
- Memory problems
- Current use of tube feeding or parental nutrition
- Patients with an active second malignancy
- Patients unable to lie still for 2 hours
- Unable to complete the cognitive task
- Pre-existing swallowing difficulties
- Allergy to gluten-, milk- or wheat products
- Self-reported hyperthyroidism
- Self-reported diabetes mellitus
- Current use of appetite stimulant medications
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cachectic COPD patients Functional magnetic resonance imaging (fMRI) Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The study participants will undergo fMRI scanning. Cachectic cancer patients Functional magnetic resonance imaging (fMRI) Cachectic cancer patients, including non-small cell lung cancer (NSCLC) and gastro-intestinal cancer. The study participants will undergo fMRI scanning. Non-cachectic COPD patients Functional magnetic resonance imaging (fMRI) Diagnosis of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The study participants will undergo fMRI scanning. Non-cachectic cancer patients Functional magnetic resonance imaging (fMRI) Non-cachectic cancer patients, including NSCLC and gastro-intestinal cancer. The study participants will undergo Functional magnetic resonance imaging (fMRI) scanning.
- Primary Outcome Measures
Name Time Method Reward-related activity in response to food cues, as indicated by Blood Oxygenation Level Dependent (BOLD) values in specified brain areas related to food reward. 2 years
- Secondary Outcome Measures
Name Time Method Blood parameters: leptin (ug/L) 2 years Blood parameters: ghrelin (pg/mL) 2 years Dietary intake assessed by a food diary 2 years Blood parameters: glucose (mmol/L) 2 years Blood parameters: insulin (pmol/L) 2 years Blood parameters: glucagon-like peptide-1 (pmol/L) 2 years
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link peripheral satiety hormones to altered food reward circuitry in cachexia patients with COPD or pancreatic cancer?
How does modulation of the food reward system in cachexia compare to standard nutritional interventions in improving caloric intake?
Which biomarkers correlate with food reward circuitry activity in cachexia induced by lung cancer or chronic obstructive pulmonary disease?
What adverse events are associated with targeting the food reward system in cachexia, and how are they managed in clinical practice?
Are there existing pharmacological agents targeting ghrelin or leptin pathways for cachexia treatment, and what are their efficacy profiles?
Trial Locations
- Locations (1)
Maastricht UMC
🇳🇱Maastricht, Limburg, Netherlands