Association between viral and bacterial infections and the pathogenesis of acute appendicitis in childre

Withdrawn

• Conditions: 10017969; Appendicitis; inflammation of the appendix

• Registration Number: NL-OMON43102
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 248

Inclusion Criteria

Children between 5 and 18 years old, who are referred by first line health care with the suspicion of acute appendicitis.
Healthy children between 5 and 18 years old

Exclusion Criteria

Severe co-morbidity like malignancy, resent abdominal surgery and known inflammatory bowl disease.
Pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the bacteria and viruses present, and their<br /><br>mutual frequence ratio, in the wall of the resected inflamed appendix together<br /><br>with the presence of these bacteria and gastrointestinal viruses in feces and<br /><br>the viruses in the blood samples.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other parameters that will be analyzed are patient factors like diagnosis<br /><br>(perforated or non-perforated appendicitis), age and gender. Furthermore,<br /><br>information on possible confounding factors, such as use of antibiotics or<br /><br>other medicine, use of probiotics, and diet, will be collected.</p><br>