Hyperprolactinemia and Adrenal Steroidogenesis: is There a Link?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Covariation of plasma prolactin and plasma dehydroepiandrosterone
研究概览
简要总结
The purpose of this study is to explore the effects of prolactin on adrenal steroid profiles in patients with hyperprolactinemia due to prolactinomas before and after initialisation of treatment.
详细描述
Prolactin is known to influence many biological processes. One potential target is the adrenal gland, where prolactin may stimulate the production of adrenal steroid hormones. Conditions of increased prolactin production(hyperprolactinemia) could, therefore, increase concentrations of adrenal steroids. One of the potential implications would be false doping accusations of athletes engaging in elite sports.
This interaction between prolactin and adrenal steroidogenesis, however, remains poorly understood, and the available research findings are conflicting.
The investigators, therefore, seek to explore the relationship between prolactin and adrenal steroidogenesis by monitoring prolactin levels and blood and urinary steroid profiles of patients with hyperprolactinemia due to prolactinomas before and after treatment initialisation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years or older
- •Female and pre-menopausal
- •Serum prolactin > 150 ng/ml
排除标准
- •Corticotropic and/or thyreotropic insufficiency
- •Pregnancy, planned pregnancy or breastfeeding
- •Physical or psychological condition likely to interfere with the normal conduct of the study and interpretation of the study results as judged by the investigator
- •Incapacity to give informed consent
结局指标
主要结局
Covariation of plasma prolactin and plasma dehydroepiandrosterone
时间窗: From pre-treatment till 5 weeks of treatment
Covariation of plasma prolactin and plasma dehydroepiandrosterone over time
次要结局
- Change in the urine steroid profile(From pre-treatment till 5 weeks of treatment)
- Change in the plasma steroid profile(From pre-treatment till 5 weeks of treatment)
- Covariation of urinary adrenal steroids(From pre-treatment till 5 weeks of treatment)
- Change in plasma prolactin levels(From pre-treatment till 5 weeks of treatment)