A Randamized double-blind comparative study evaluating the efficacy of a combination of PREGABALIN and DULOXETINE versus PREGABALIN alone and the modulation of mRNA expression of PPARG and Akt genes in patients of painful Diabetic peripheral neuropathy

IVERSITY COLLEGE OF MEDICAL SCIENCES0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

研究概览

暂无简介。

•1.Male or female patientsâ?? >= 18 years of age with pain due to diabetic peripheral neuropathy
•caused by type -I or II Diabetes mellitus for at least 3 months with confirmed diagnosis
•on Michigan Neuropathy Screening instrument with score >=3 at the time of screening.
•2.Patients must have average pain severity of >= 4/10 on NRS.
•3. Brief Pain Inventory- Modified short form (BPI- MSF) >= 4.
•4.Patients should have stable glycemic control with HbA1C < 12%.

•1.Patients who had received duloxetine or pregabalin in the past except for less than 15
•days course.
•2. Evidence of other sources of pain that may confound the diagnosis or recent history of
•3.Patients with past history of MI, liver disease, pancreatitis and vasculitis, heart failure,
•seizure, & arrhythmia.
•4. Patients with evidence of renal impairment, diabetic foot ulcer/gangrene of the foot &
•history of alcohol consumption and smoking.

发起方

IVERSITY COLLEGE OF MEDICAL SCIENCES