Comparison of effect of two different doses of oral Pregabalin in reducing postoperative analgesia in patients receiving neuraxial anaesthesia for surgical procedures - A randomized controlled trial

A total of 90 patients belonging to the age group of 18-65 years, assessed under ASA I and ASA II, scheduled for elective surgeries under spinal anesthesia blockade will be prospectively studied. In this double-blinded randomised controlled trial, a total of 90 participants will be allocated into three groups- Group A(Conventional Spinal Anaesthesia), Group B(150mg T.Pregabalin preoperatively) and Group C(300mg T.Pregabalin preoperatively). Patients will receive either their allocated drug or a placebo in the conventional group 1 hour before surgery. Their level of sedation will be assessed after the hour using Ramsay Sedation Scale before shifting the patients to the OT. All patients will receive 0.5% hyperbaric bupivacaine 0.3mg/kg intrathecally at L3-L4 space with 25G Quincke needle under aseptic precautions. All patients will be assessed for their pain using the Visual Analogue Scale postoperatively for 24 hours. Data collection will be done by observation and measurement of various parameters.