effect of selenium on oxidative stress status and inflammatory factors in post gastrointestinal surgery childre

Phase 3

Recruiting

Conditions: Condition 1: Digestive System Surgical Procedures. Condition 2: selenium deficiency. Condition 3: Congenital diaphragmatic hernia. Condition 4: Acute abdomen. Condition 5: Congenital malformations of esophagus. Condition 6: Other specified congenital malformations of upper alimentary tract. Condition 7: Congenital disorders of small intestine. Condition 8: Congenital disorders of large intestine. Condition 9: Congenital malformations of gallbladder, bile ducts and liver.
Unspecified intestinal obstruction
Sequelae of other nutritional deficiencies
Congenital diaphragmatic hernia
Acute abdomen
Congenital malformations of esophagus
Other congenital malformations of upper alimentary tract
Congenital absence, atresia and stenosis of small intestine
Congenital absence, atresia and stenosis of large intestine
Congenital malformations of gallbladder, bile ducts and liver

Registration Number: IRCT20190122042449N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

0-10 years old patients undergoing major gastrointestinal surgery at the Akbar Hospital of Mashhad
Admission to the intensive care unit due to medical indications
Filling out the informed consent form by a parent or legal guardian
Stability of hemodynamic and metabolic status in the first 24 to 48 hours

Exclusion Criteria

Patients who are not allowed to start a nutrition support care for them within the first 24-48 hours
Diagnosed autoimmune disorders
Diagnosed cancers
Severe sepsis at the admission time
History of chemotherapy and radiotherapy in the past month
Diagnosed renal failure
Diagnosed severe hepatic failure
Severe and active bleeding
A known case of human immunodeficiency virus
Preterm neonates

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pro-oxidant- Antioxidant Balance (PAB) status. Timepoint: before intervention and after 10 days. Method of measurement: Pro-oxidant- Antioxidant Balance (PAB) assay.;Inflammatory factors. Timepoint: before intervention and after 10 days. Method of measurement: Interleukin 1 beta: ELISA, high-sensitivity C-reactive protein (hs-CRP) test: Immunoturbidimetry.

Secondary Outcome Measures

Name	Time	Method
Serum and urine selenium Level. Timepoint: before intervention and 1, 10 days after intervention. Method of measurement: atomic absorpsion.;Serum Glutathione peroxidase level. Timepoint: before intervention and 1, 10 days after intervention. Method of measurement: ELISA.