The effects of submucosal administration of methylprednisolone and dexamethasone in comparison to control group on pain, swelling, and trismus after third molar surgery

Phase 2

• Conditions: Third molar surgery; Pericoronitis; Surgery - Other surgery; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12619001349134
• Lead Sponsor: Dr Kinza Ayub

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-10-01
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients in the age group – 20 to 50 years
Patients with mesioangular impactions Class II position B third molar according to the Pell and Gregory’s classification.
Patient with no medical conditions

Exclusion Criteria

•Patients requiring prophylactic antibiotics before surgical procedure. The following patients will be excluded because taking antibiotic before the treatment will subside the infection and pain and it will act as confounding factor with the study design
•Patients suffering from any mental disorders or with any chronic pain problems. The following patients will be excluded because of ethical concerns.
•Pregnant or lactating women. The following patients will be excluded to avoid any harm to pregnancy and fetus.
•Patients reporting hypersensitivity to steroids. The following patients will be excluded because intervention includes application of steroids and they can have hypersensitivity or anaphylactic reaction
•Patients taking nonsteroidal anti-inflammatory drugs in the 3 days before participation in the study. The following patients will be excluded because taking NSAIDS before the treatment will subside the infection and pain and it will act as confounding factor with the study design
•Patients having acute pulpitis, abscesses, or other acute infections. The following patients will be excluded because of ethical concerns.
•Patients with systemic disorders
•Patients on long-term steroids

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post op trismus will be evaluated on 2st, 3rd and 7th post op day. <br> Trismus will be evaluated through measuring the interincisal opening at 2st ,3rd and 7th day.<br><br><br><br>[3rd primary time point<br> 2nd and 7th post op day post enrollment days];Post op swelling will be evaluated on 2st, 3rd and 7th post op day. <br>Swelling will be evaluated by measuring the distance between tragus of ear and corner of mouth and then tragus of ear and progonion. The mean of two measurements will be recorded. <br><br>[3rd post op day is primary time point<br>2nd nd 7th post op day is post enrollment time]

Secondary Outcome Measures

Name	Time	Method
Pain will be evaluated through the Vas score [2nd,3rd and 7th post op day];Number and time of analgesics taken described by the patient. The patient will keep a record in his diary [2nd, 3rd and 7th post op day]