Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Selenium Status
- Sponsor
- Danish Cancer Society
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Selenium concentration in whole blood
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels.
The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.
Detailed Description
Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.
Investigators
Eligibility Criteria
Inclusion Criteria
- •men and women
- •50-74 years
- •BMI 18.5-28 kg/m2
- •non-smokers
Exclusion Criteria
- •strenuous exercise \> 10 h/week
- •excessive intake of alcohol
- •frequent intake of fish and shellfish \> 200-300 g/week
- •intake of dietary supplements 3 months before or during the study
- •frequent use of medication except antihypertensive medicine, cholesterol lowering medicine and hormone replacement medicine
- •simultaneous participation in other research projects
- •cancer diagnosis within the past 5 years
- •severe chronic diseases
Outcomes
Primary Outcomes
Selenium concentration in whole blood
Time Frame: Measured after 6 months of intervention
Secondary Outcomes
- Selenoprotein P in plasma(Measured after 6 months of intervention)
- Genetic polymorphisms in the selenoprotein P gene(Measured after 6 months of intervention)
- Heavy metals in whole blood (lead, cadmium, and mercury)(Measured after 6 months of intervention)
- Blood pressure(Measured after 6 months of intervention)
- Anthropometry (weight, height, waist, and hip circumference)(Measured after 6 months of intervention)