Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Selenium concentration in whole blood
研究概览
简要总结
The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels.
The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.
详细描述
Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •men and women
- •50-74 years
- •BMI 18.5-28 kg/m2
- •non-smokers
排除标准
- •strenuous exercise > 10 h/week
- •excessive intake of alcohol
- •frequent intake of fish and shellfish > 200-300 g/week
- •intake of dietary supplements 3 months before or during the study
- •frequent use of medication except antihypertensive medicine, cholesterol lowering medicine and hormone replacement medicine
- •simultaneous participation in other research projects
- •cancer diagnosis within the past 5 years
- •severe chronic diseases
研究组 & 干预措施
Fish and shellfish
干预措施: Fish and shellfish (Dietary Supplement)
Control
Assessment only
结局指标
主要结局
Selenium concentration in whole blood
时间窗: Measured after 6 months of intervention
Selenium concentration in whole blood
时间窗: Measured at baseline
Selenium concentration in whole blood
时间窗: Measured after 3 months of intervention
次要结局
- Selenoprotein P in plasma(Measured after 6 months of intervention)
- Genetic polymorphisms in the selenoprotein P gene(Measured after 6 months of intervention)
- Heavy metals in whole blood (lead, cadmium, and mercury)(Measured after 6 months of intervention)
- Blood pressure(Measured after 6 months of intervention)
- Anthropometry (weight, height, waist, and hip circumference)(Measured after 6 months of intervention)
- Selenoprotein P in plasma(Measured at baseline)
- Selenoprotein P in plasma(Measured after 3 months of intervention)
- Genetic polymorphisms in the selenoprotein P gene(Measured at baseline)
- Genetic polymorphisms in the selenoprotein P gene(Measured after 3 months of intervention)
- Heavy metals in whole blood (lead, cadmium, and mercury)(Measured at baseline)
- Heavy metals in whole blood (lead, cadmium, and mercury)(Measured after 3 months of intervention)
- Blood pressure(Measured at baseline)
- Blood pressure(Measured after 3 months of intervention)
- Anthropometry (weight, height, waist, and hip circumference)(Measured at baseline)
- Anthropometry (weight, height, waist, and hip circumference)(Measured after 3 months of intervention)