Obstructive Sleep Apnoea and Associated Metabolic/Cardiovascular Disorders: Understanding Mechanisms Towards Early Diagnosis and Prognosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Percentage of patients with clinical improvement
研究概览
简要总结
Untreated Obstructive Sleep Apnea Syndrome (OSAS) has long-term complications, namely metabolic imbalances (obesity, dislipidemia, type 2 diabetes mellitus). Until now, no molecular markers for this physiopathological connection have been identified.
This project aims to determine non-invasive biomarkers that may allow better comprehension of the metabolic consequences of OSAS, as well as assess the effect of Continuous positive airway pressure (CPAP) on these metabolic parameters.
This project will integrate the clinical, metabolic, genetic/proteomic and biologic systems to further explore the mechanisms behind OSAS, as well as the effect of the treatment with CPAP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •25-60 years
- •Mild/Moderate/Severe OSAS
排除标准
- •Other sleep disorders
- •Previous CPAP therapy
- •Type 1 diabetes mellitus
- •Familiar Dyslipidemia
- •Severe organ pathology
- •Acute disease
结局指标
主要结局
Percentage of patients with clinical improvement
时间窗: 6 months
Treatment efficacy of CPAP will be assessed at the end of treatment through a clinical observation.
次要结局
- Frequency of occurence of biomarkers(6 months)