NCT03763773已完成不适用
Prediction of Outcomes With a Miniaturized Transesophageal Echocardiography Probe in Patients With Acute Respiratory Distress Syndrome
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2019年4月21日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Number of days lived without mechanical ventilation
研究概览
简要总结
The Superior Vena cava Respiratory Collapse Index (cVCS) is a haemodynamic parameter measured exclusively by transoesophageal ultrasound (TEE), which is used to assess cardiac precharge-dependence status. This may be an important prognostic factor in ARDS because it is a sign of hypervolemia and right heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients hospitalized in Resuscitation, Emergency or Intensive Care Units at the Roger Salengro Hospital at Lille University Hospital.
- •With acute respiratory distress syndrome of intermediate or severe severity (1) for less than 24 hours.
- •Mechanical ventilation with tracheal intubation or tracheostomy, in controlled assisted ventilation (VAC) mode.
- •Patient adapted to mechanical ventilation (no triggering of spontaneous ventilation cycle in VAC mode verified by the equality between the respiratory rate prescribed on the ventilator and the actual respiratory rate of the patient).
排除标准
- •Patient under extracorporeal respiratory assistance at the time of inclusion.
- •Anomalies or pathologies that make it dangerous or impossible to introduce an ETO probe:
- •Fistula, perforation, stenosis, varicose vein or diverticulum of the esophagus and / or stomach
- •History of esophageal and / or gastric surgery
- •Caustic lesions of the esophagus and / stomach
- •Tumor or history of oropharyngeal surgery
- •Unstable lesions of the cervical spine
- •Coagulopathy (thrombocytopenia <50 109 / L and / or TP <50%).
- •Impossibility of measuring the diameter of the superior vena cava and cVCS in ETO due to poor echogenicity.
- •Pregnant woman.
- •Therapeutic limitation measures limiting the treatment of organ failure.
结局指标
主要结局
Number of days lived without mechanical ventilation
时间窗: at 28 days
This variable will be defined as follows:duration = 28 -x -y. where x is the number of days living under mechanical ventilation during the first 28 days and the number of days in the first 28 days.
次要结局
- number of patient of death(At 28 days, at 90 days)
研究者
研究点 (1)
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