Microperimetric Evaluation After Half-dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Not Applicable

Completed

• Conditions: Chronic Central Serous Chorioretinopathy
• Interventions: Procedure: half-dose photodynamic therapy

• Registration Number: NCT01434095
• Lead Sponsor: Surugadai Nihon University Hospital

Brief Summary

A half-dose photodynamic therapy, a relative new treatment, has been widely performed to treat central serous chorioretinopathy.

The researchers aimed to investigate whether the therapy improved the patient's visual acuity as well as the retinal sensitivity. The researchers also investigate which clinical factors, if any, were associated with the results; visual acuity or retinal sensitivity after the treatment.

Detailed Description

The best-corrected visual acuity (BCVA), macular sensitivity, and fixation stability were evaluated at the baseline and at 1, 3, 6, and 12 months after the half-dose photodynamic therapy. The macular sensitivity and fixation stability were determined by MP-1 microperimetry (Nidek, Vigonza, Italy). The researchers analysed whether the BCVA and retinal sensitivity significantly improved or not. And if yes, the researchers were interested at which period after treatment the significant improvement was found. Also, the researchers investigated which improved first, BCVA or retinal sensitivity.

Study Timeline

• Study Start: 2008-10
• Primary Completion: 2010-07
• Study Completion: 2010-07
• Status Verified: 2011-09
• Study First Submitted: 2011-09-13
• Study First Submitted QC: 2011-09-13
• Study First Posted: 2011-09-14
• Last Update Submitted: 2011-09-14
• Last Update Posted: 2011-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• the presence of subretinal fluid involving the fovea in the Optical coherence tomographic (OCT) images
• a serous retinal detachment of at least 6 months duration.

Exclusion Criteria

• evidence of a choroidal neovascularization (CNV), polypoidal choroidal vasculopathy, or other maculopathy documented by fluorescein angiography or Indocyanine green angiography

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
half-dose PDT(photodynamic therapy)	half-dose photodynamic therapy	The study include single arm; treated group, and no control group was included.

Primary Outcome Measures

Name	Time	Method
best corrected visual acuity	one year

Secondary Outcome Measures

Name	Time	Method
retinal sensitivity	one year

Trial Locations

Locations (1)

Department of Ophthalmology, Surugadai Nihon University Hospital; 🇯🇵 Chiyoda-ku, Tokyo, Japan