Investigations Regarding B-cell Subsets in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 249
- 试验地点
- 1
- 主要终点
- Presence of B-1 cells in humans
研究概览
简要总结
The aim of this research is to define the human equivalent of mouse B1 cells.
详细描述
The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli.
The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject is considered by the physician to be a healthy adult.
排除标准
- •Subject is under the age of 18
- •Subject has an infection or is currently ill
结局指标
主要结局
Presence of B-1 cells in humans
时间窗: determined over the years study in effect
an equivalent cell type was isolated in humans
次要结局
未报告次要终点
研究者
Daniel Griffin
Fellow Infectious Diseases
Northwell Health