Gait, cOgnitiOn & Decline (GOOD)

• Conditions: Mild Dementia; Healthy; Moderate Dementia; Mild Cognitive Impairment
• Interventions: Other: gait and cognitive testing

• Registration Number: NCT02350270
• Lead Sponsor: University Hospital, Angers

Brief Summary

The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.

Detailed Description

Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.

The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.

Study Timeline

• Status Verified: 2014-02
• Study Start: 2015-01
• Study First Submitted: 2015-01-26
• Study First Submitted QC: 2015-01-28
• Last Update Submitted: 2015-01-28
• Study First Posted: 2015-01-29
• Last Update Posted: 2015-01-29
• Primary Completion: 2015-06
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2800

Inclusion Criteria

• Being 60 years old and older
• Ability to answer questions

Exclusion Criteria

• Opposition to the use of information collected for research purposes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cognitively healthy individuals (CHI)	gait and cognitive testing	CHI were participants without objective cognitive impairment
mild and moderate dementia	gait and cognitive testing	Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences
mild cognitive impairment (MCI)	gait and cognitive testing	MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment

Primary Outcome Measures

Name	Time	Method
Spatio-temporal gait parameters	This outcome is assessed at inclusion	Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system.

Secondary Outcome Measures

Name	Time	Method
Clinical assessment	This outcome is assessed at inclusion	This outcome was assessed by a questionnaire.
Cognitive status	This outcome is assessed at inclusion	Cognitive status was assessed by cognitive testing.

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Angers, France