Comparison of two drugs in spinal anaesthesia for lower limb orthopaedic surgeries

Not yet recruiting

Lead Sponsor: Department of AnaesthesiologyGoverment medical college bhavnagar

Brief Summary: Spinal anesthesia is the most common used technique for lower limb orthopaedic surgeries. Local anaesthetic like bupivacaine alone when used, may not be able to give longer duration of action so it is beneficial to use it with adjuvants like dexmedetomidine and Mgso4. So in this study we are studying the effects of adding dexmedetomidine and Mgso4 as an adjuvat to bupivacaine for sub-arachnoid block.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Participants having contraindications to subarachnoid block like congenital spinal anomalies, altered coagulation profile, local site skin infection. Participants having severe psychiatric disorders like depression, dementia or any other psychiatric illness and are not compatible for subarachnoid block.
Participants having neurological diseases like brain tumour, CNS syphilis, meningitis. Spinal cord and peripheral nerve diseases, poliomyelitis, multiple sclerosis. Participants with allergy to local anaesthetic drug or study drug. Pregnant lady and lactating mother. Chronic headache. eg.migraine.

Primary Outcome Measures

Name	Time	Method
To compare the onset, peak, duration and regression of sensory and motor blockage in both groups.	To measure vitals, and semsory and motor block effects at specific time interval. Time 0, after immediately giving spinal anaesthesia, and then at the time point of 1,2,3,5,10,15,30,60,90,120 mins and for post operative analgesia and effect regression 4 hours post operatively.
To compare the onset, peak, duration and regression of motor blockage in both groups.	To measure vitals, and semsory and motor block effects at specific time interval. Time 0, after immediately giving spinal anaesthesia, and then at the time point of 1,2,3,5,10,15,30,60,90,120 mins and for post operative analgesia and effect regression 4 hours post operatively.
To compare period of postoperative analgesia in both groups.	To measure vitals, and semsory and motor block effects at specific time interval. Time 0, after immediately giving spinal anaesthesia, and then at the time point of 1,2,3,5,10,15,30,60,90,120 mins and for post operative analgesia and effect regression 4 hours post operatively.

Secondary Outcome Measures

Name	Time	Method
to compare heamodynemic status of pt, and any side effects.	Time 0(immediately after block) and then at 1,2,3,5,10,15,30,60,90,120 mins.

Locations (1): Sir t hospital
🇮🇳
Bhavnagar, GUJARAT, India
Sir t hospital
🇮🇳Bhavnagar, GUJARAT, India
Dr Meha Pathak
Principal investigator
9409442734
pathak_meha@yahoo.com