Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- strain ratio
研究概览
简要总结
Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.
详细描述
This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 86 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group
- •No knee pain or received injection during the past 1 year
- •No history of knee OA
排除标准
- •History of knee surgery, trauma or malignancy
- •History of patellar tendinopathy or patellofemoral pain syndrome
- •Refused informed consent
结局指标
主要结局
strain ratio
时间窗: before and 1-3 months after hyaluronic acid injection
the semiquantitative measurement of elasticity of Hoffa's fat pad, a ratio with patellar tendon as reference
shear modulus
时间窗: before and 1-3 months after hyaluronic acid injection
the absolute quantitative measurement of elasticity (kPa) of Hoffa's fat pad
thickness of Hoffa's fat pad
时间窗: before and 1-3 months after hyaluronic acid injection
the thickness of Hoffa's fat pad from mid patellar tendon to femur cartilage
次要结局
未报告次要终点