Acute Neurochemical and Cognitive Responses to High Intensity Interval Training vs. Moderate- and Low-Intensity Continuous Training in Young Adult Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Lactate
研究概览
简要总结
This study examines whether the intensity of a single running session changes a blood marker related to brain health (brain-derived neurotrophic factor, BDNF), blood lactate, and performance on a short thinking task that measures attention and self-control (the Stroop test) in healthy young adult men.
Twelve healthy males (18-25 years) will complete four separate sessions in a randomized, counterbalanced order, with at least 7 days between sessions. Each session includes an 8-minute warm-up followed by 24 minutes of one of the following conditions: low-intensity continuous running, moderate-intensity continuous running, high-intensity interval running (repeated 15-second fast runs with 15-second passive rest, organized into sets), or a seated rest control session. Running pace will be individualized based on a prior fitness test.
A small venous blood sample (about 8 mL) will be collected immediately before and within 1 minute after each session. After each session, participants will complete the Stroop test. The main outcomes are the before-to-after changes in serum BDNF, blood lactate, and Stroop test performance across the four conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged between 18 and 25 years
- •No known medical condition that prevents participation in exercise
- •Not currently using any pharmacological agents
排除标准
- •Experiencing any discomfort before, during, or after exercise
- •Current or past diagnosis of pharmacological or doping substance use
- •Engaging in regular exercise (more than 3 times per week) within the last 2 weeks
- •History of alcohol or substance addiction
- •Any other condition or factor that may prevent full participation in the study protocol
研究组 & 干预措施
Control
Participants remained seated quietly at rest for 24 minutes in a quiet, well-lit room, matched to the exercise sessions for time schedule and environmental conditions. No physical activity was performed during this period.
Low-intensity continuous training
They were asked to perform low intensity exercise for the specified time, determined according to their maximal oxygen consumption capacity.
干预措施: Low Intensity Exercise (Behavioral)
Moderate-intensity continuous training
They were asked to perform moderate intensity exercise for the specified time, determined according to their maximal oxygen consumption capacity.
干预措施: Moderate-Intensity Continuous Exercise (Behavioral)
High-intensity interval training
They were asked to perform HIIT exercise for the specified time, determined according to their maximal oxygen consumption capacity.
干预措施: High-Intensity Interval Training (Behavioral)
结局指标
主要结局
Lactate
时间窗: Baseline, Immediately After Exercise (Day 1)
Lactate levels were measured in millimoles per liter (mmol/L) from capillary/venous blood samples taken before and after exercise using a lactate analyzer.
BDNF
时间窗: Baseline, Immediately After Exercise (Day 1)
BDNF levels were measured using a Sunred brand ELISA kit from blood samples taken baseline and after exercise, and the results were reported in ng/mL units.
Stroop Test
时间窗: Baseline and immediately after exercise (Day 1)
Stroop test performance will be assessed as an indicator of executive function, primarily selective attention and inhibitory control. In this task, participants are required to identify the ink color of presented stimuli while suppressing the automatic tendency to read the written word, particularly during incongruent trials (e.g., the word "red" printed in blue ink). The test will be administered immediately after each session. Outcomes will include reaction time and accuracy (and/or an interference score derived from incongruent vs. congruent conditions). Reaction time will be recorded in seconds (s), with poorer performance reflected by slower responses and/or more errors.
次要结局
未报告次要终点
研究者
serkan pancar
Assoc. Prof.
Aksaray University Training and Research Hospital