A Prospective, Randomized Comparison of Coronary Artery Bypass Grafting Based on COmputed Tomography-derived Fractional Flow REserve Versus Angiography (CABG-COREA Trial)
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Myongji Hospital
- Enrollment
- 96
- Locations
- 1
- Primary Endpoint
- 1-Year graft patency rates
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed tomography(CT)-derived fractional flow reserve(FFR), and (2) to demonstrate difference in clinical outcomes between the 2 groups.
Detailed Description
The CABG-COREA trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography (quantitative coronary angiography) or cardiac computed tomography-derived fractional flow reserve according to the randomization result. The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).
Investigators
Min-Seok Kim
Associate Professor
Myongji Hospital
Eligibility Criteria
Inclusion Criteria
- •age equal or more than 40
- •age equal or less than 80
- •patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease
- •patients who agree to the enrollment
Exclusion Criteria
- •Patients with heart failure (left ventricular ejection fraction \< 25%)
- •patients who have intractable ventricular arrhythmia
- •patients who has been treated for cancer
- •patients who has infectious disease
- •patients who are planned to undergo combined cardiac surgery
- •patients who has medical co-morbidity with expected survival less than 1 year
- •patients with a history of previous cardiac surgery
- •Patients with chronic renal failure requiring dialysis
- •patients who undergo emergency operation
Outcomes
Primary Outcomes
1-Year graft patency rates
Time Frame: 1 year
postoperative graft patency measured by 1 year postoperative coronary angiography
Secondary Outcomes
- Early Angiographic Patency Rates(1.5 days)
- Freedom From MACCE(Major Adverse Cardiac and Cerebrovascular Events)(4 years)
- Overall survival(4 years)
- Freedom from Cardiac Death(4 years)