Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Central Motor Excitability
研究概览
简要总结
Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of Spinocerebellar ataxia
- •No history of epilepsy
- •No other neuromuscular disorder
- •No fracture within the last six months and restricted movement on the upper extremity
- •Limited trembling hand allowed for the EMG recording.
排除标准
- 未提供
结局指标
主要结局
Central Motor Excitability
时间窗: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.
Peripheral Motor Excitability
时间窗: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Measure of changes in peripheral motor excitability by Maximum M wave and H reflex
次要结局
未报告次要终点
研究者
Ya-Ju Chang
Professor
Chang Gung University