Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spinocerebellar Ataxia
- Sponsor
- Chang Gung University
- Enrollment
- 29
- Locations
- 1
- Primary Endpoint
- Central Motor Excitability
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.
Investigators
Ya-Ju Chang
Professor
Chang Gung University
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of Spinocerebellar ataxia
- •No history of epilepsy
- •No other neuromuscular disorder
- •No fracture within the last six months and restricted movement on the upper extremity
- •Limited trembling hand allowed for the EMG recording.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Central Motor Excitability
Time Frame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.
Peripheral Motor Excitability
Time Frame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Measure of changes in peripheral motor excitability by Maximum M wave and H reflex