Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia

Not Applicable

Completed

• Conditions: Spinocerebellar Ataxia
• Interventions: Device: Neuromuscular electrical stimulation

• Registration Number: NCT02103075
• Lead Sponsor: Chang Gung University

Brief Summary

Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-08
• Primary Completion: 2005-10
• Study Completion: 2005-10
• Status Verified: 2014-03
• Study First Submitted: 2014-03-31
• Study First Submitted QC: 2014-03-31
• Last Update Submitted: 2014-03-31
• Study First Posted: 2014-04-03
• Last Update Posted: 2014-04-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Clinical diagnosis of Spinocerebellar ataxia
• No history of epilepsy
• No other neuromuscular disorder
• No fracture within the last six months and restricted movement on the upper extremity
• Limited trembling hand allowed for the EMG recording.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The SCA	Neuromuscular electrical stimulation	-
The age-matched control	Neuromuscular electrical stimulation	-
The young control	Neuromuscular electrical stimulation	-

Primary Outcome Measures

Name	Time	Method
Central Motor Excitability	Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.	Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.
Peripheral Motor Excitability	Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.	Measure of changes in peripheral motor excitability by Maximum M wave and H reflex

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan