Antibiotic Resistance in Danish EDs.

Completed

• Conditions: Antibiotic Resistance, Bacterial

• Registration Number: NCT03352167
• Lead Sponsor: University of Southern Denmark

Brief Summary

The spread of multiresistant bacteria is an increasing problem which will mean increased costs, morbidity and mortality in the coming years. Emergency departments (ED) play a key role in the early identification and management of patients who are carriers of multiresistant bacteria, but today there is very limited knowledge about both prevalence in the EDs and risk factors for the carrier status of methicillin resistant Staphylococcus aureus (MRSA), extended spectrum beta lactam producing enterobacteria (ESBL), vancomycin resistant enterococci (VRE), carbapenem resistant enterobacteria (CPE) and toxin-producing Clostridium difficile (CD). This knowledge is necessary to prioritize and target the preventive response to the spread of multiresistant bacteria.

The aim of this project is to provide a comprehensive overview of prevalence and risk factors for carrier status at a national level, and to develop screening tools for early identification of MRSA, ESBL, VRE, CPE and CD carriers among patients admitted to Danish emergency departments.

For hospitalized patients in 8 emergency departments in 4 Danish regions, a total of 10,600 patients are asked for possible risk factors for resistant bacterial carrier status, and are swabbed in the throat, nose and rectum openings and examined for MRSA, VRE, CPE, ESBL and CD with the same analytical method of 4 clinical microbiological departments.

The results are analyzed so that the prevalence of resistant bacteria can be described at the hospital level, regional level and national level. Risk factors are analyzed for applicability for carrier identification, and based on this, screening models for the identification of carriers are developed.

The vision for the project is that, based on the collected data, a comprehensive picture of the extent of the problem in Denmark can be drawn up and new screening tools for early identification of carriers can be developed so that the intra-hospital spread of resistant bacteria can be met through early intervention with infectious hygiene measures.

The project has been granted a grant of DKK 3,000,000 from the Ministry of Health and the Elderly on December 7, 2016 and DKK 554,871 from the Region of Southern Denmark on 28 August 2017.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-11-20
• Study First Submitted QC: 2017-11-20
• Study First Posted: 2017-11-24
• Study Start: 2018-01-08
• Primary Completion: 2018-05-01
• Study Completion: 2018-07-01
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-25
• Last Update Posted: 2021-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5117

Inclusion Criteria

Not provided

Exclusion Criteria

• admitted more than 16 hours before inclusion
• no operation in rectum less than 2 weeks before the admission

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bacterial Antibiotic Resistance	baseline observation only

Trial Locations

Locations (8)

Hospital of Southern Jutland; 🇩🇰 Aabenraa, Denmark

Aalborg University Hospital; 🇩🇰 Aalborg, Denmark

Aarhus Univerisity Hospital; 🇩🇰 Aarhus, Denmark

Herning Hospital; 🇩🇰 Herning, Denmark

Hjørring Hospital; 🇩🇰 Hjørring, Denmark

Køge University Hospital; 🇩🇰 Køge, Denmark

Odense University Hospital; 🇩🇰 Odense, Denmark

Slagelse Hospital; 🇩🇰 Slagelse, Denmark