Ventilatory Weaning Guided by a New Index
- Conditions
- Respiration, Artificial
- Interventions
- Device: Timed Inspiratory Effort (TIE index)
- Registration Number
- NCT04512677
- Lead Sponsor
- Universidade Federal Fluminense
- Brief Summary
Mechanical ventilation (MV) is an essential therapy for patients with acute respiratory failure. The ventilatory weaning process should be started when the precipitating causes of the use of the ventilatory prosthesis are resolved. Inappropriately slow weaning exposes the patient to unnecessary discomfort, increases the risk of complications and increases the cost of hospital treatment. In this sense, indices that can predict successful weaning are of great value.
- Detailed Description
Mechanical ventilation (MV) is an essential therapy for patients with acute respiratory failure. The ventilatory weaning process should be started when the precipitating causes of the use of the ventilatory prosthesis are resolved. Inappropriately slow weaning exposes the patient to unnecessary discomfort, increases the risk of complications and increases the cost of hospital treatment. In this sense, indices that can predict successful weaning are of great value. Our study aimed to evaluate the performance of a new ventilatory weaning index, the timed inspiratory effort index (TIE index), as a weaning predictor in comparison with the traditionally used spontaneous breathing test (SBT). The study is a randomized controlled trial of a cohort of mechanically ventilated patients over 24 hours admitted to the ICU of Hospital e Clínica São Gonçalo (HCSG), located in the city of São Gonçalo, State of Rio de Janeiro, Brazil. The TIE index is calculated as the ratio of the maximum inspiratory pressure developed in the last 30 seconds of a 60 second period of unidirectional airway occlusion by the time required to reach this value.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 144
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental: Intervention Timed Inspiratory Effort (TIE index) Conventional clinical treatment and using the Timed Inspiratory Effort (TIE index), which guided the decision to ventilate weaning and extubation.
- Primary Outcome Measures
Name Time Method Sucessful weaning Two years Compare the timed inspiratory effort index parameter TIE as an indicator of weaning compared to the spontaneous breathing test
- Secondary Outcome Measures
Name Time Method Frequency of failure at weaning Two years Compare the frequency of failure at weaning when using the TIE index or the T-piece TRE as a criterion for extubation.
Counting of the number of tests needed until extubation Two years Evaluate the number of tests required until the decision favorable to extubation was made in both groups.
Comparison of the length of stay in the ICU Two years Compare the length of stay in the ICU between extubation, discharge or death counted from extubation among patients who used the TIE or SBT index in T piece.
Trial Locations
- Locations (2)
Universidade Federal Fluminense
🇧🇷Niterói, Rio De Janeiro, Brazil
Hospital e Clínica São Gonçalo
🇧🇷São Gonçalo, Rio De Janeiro, Brazil