Energy Expenditure in Patients With Ulcerative Colitis Undergoing Surgery
- Conditions
- Ulcerative ColitisSurgery
- Interventions
- Diagnostic Test: Indirect Calorimetry
- Registration Number
- NCT06221995
- Lead Sponsor
- Evangelismos Hospital
- Brief Summary
A prospective observational study to assess the energy needs of Ulcerative Colitis patients undergoing total proctocolectomy with ileoanal j-pouch anastomosis.
- Detailed Description
Total proctocolectomy with creation of ileoanal j-pouch anastomosis is the gold-standard surgical procedure for familial polyposis, for ulcerative colitis unresponsive to medication and for colitis associated with dysplasia requiring total colectomy.
Patients postoperatively face difficulties in maintaining their physical condition and quality of life due to potential complications such as surgical, mechanical, inflammatory and functional disorders increasing the rates of malnutrition. Postoperative changes as regards anthropometric characteristics and nutritional status have not been fully elucidated.
Therefore, the need arises to calculate the energy needs of patients with ileoanal j-pouch anastomosis, given the lack of corresponding data and the possible differentiation of energy needs from a similar group of patients undergoing colorectal surgery.
Of particular interest is the body composition of ileoanal anastomosis patients, which has been studied very little ), and the extent to which their energy needs are met, given dietary restrictions both preoperatively and postoperatively.
It is therefore necessary to determine the energy needs, as well as the degree of their coverage by the diet, of UC patients undergoing proctocolectomy with creation of ileoanal j-pouch anastomosis.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
- Patients with ulcerative colitis and planned proctocolectomy with ileoanal j-pouch anastomosis surgery or patients who are to undergo subtotal colectomy.
- Age over 18 years.
- Written informed consent to take part in the study.
- Speaking ability in Greek or English.
- Able to get tested fasted;
- Age under 18 years.
- Existence of pregnancy.
- Inability to breathe inside the indirect calorimetry mask for the time required for the measurement.
- Use of medications that may affect body metabolism will be evaluated individually (e.g. cortico-steroids etc.)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Ulcerative Colitis patients undergoing proctocolectomy Indirect Calorimetry Measurement of resting energy expenditure among patients with Ulcerative Colitis about to undergo proctocolectomy with ileoanal j-pouch anastomosis
- Primary Outcome Measures
Name Time Method Amount of resting energy expenditure (kcal/day) Before surgery, 1 week postoperatively, 3 months postoperatively To evaluate total energy needs of patients who undergo proctocolectomy with ileoanal j-pouch
- Secondary Outcome Measures
Name Time Method IBDQ Before surgery and 1 week after Surgery Inflammatory Bowel Disease Questionnaires (IBDQ), a widely used questionnaire for HRQoL assessment in patients with inflammatory bowel diseases (IBDs)
Resting energy expenditure change (kcal/day) 1 week postoperatively and 3 months postoperatively Changes in daily energy expenditure after surgery compared to pre surgery assesment.
Bristol stool form scale, min: type 1 (hard solid stools, better outcome) - max: type 7 (liquid stools, worst outcome) Before surgery, 1 week postoperatively, 6 months after surgery Longitudinal changes in Bristol stool form scale score before and after surgery.
Post operative weight loss 1 week postoperatively, 3 months postoperatively Post operative weight loss will be assessed by measuring the post weight on the date of surgery and adjusting for the baseline weight in kg.
Post operative Energy intake. 1 week postoperatively, 3 months postoperatively Total energy intake measured in calories after surgery.
Trial Locations
- Locations (1)
Evangelismos General Hospital of Athens
🇬🇷Athens, Attica, Greece